Dated 11 January 2022: I started watching Akebi-chan no Sailor Fuku because it's part of the 100-friends anime trilogy
Well, it didn't come up at all during the first episode, but the promotional material for Akebi-chan no Sailor Fuku (Akebi's Sailor Uniform) states Akebi wants to make 100 friends at her new school. This is the same goal Shouko expresses in Komi-san wa, Comyushou desu. (Komi Can't Communicate) (the best show from the Autumn 2021 anime season, incidentally). I didn't know anything else about the series before I started watching it (although I was spoiled about the twist), but it seems like it's going to be one of those shows where there's not a whole lot of drama. The first classmate she meets might actually be a nutjob, so I can't rule out the possibility the show is full of weirdos. That's just speculation on my part, though.
Oh, if you haven't worked out yet what the third show in the 100-friends anime trilogy is, it's B Gata H Kei (Yamada's First Time). After graduating from middle school, Yamada sets a goal for herself to land 100 sex friends. I guess she doesn't technically express any interest in the friends part, but I'm going to include it. I'm going to include it because B Gata H Kei is an underrated masterpiece.